186028-79-5 Synthetic Research Chemicals Methylone Serotonin Norepinephrine Reuptake Inhibitors

186028-79-5 Synthetic Research Chemicals Methylone Serotonin Norepinephrine Reuptake Inhibitors​

Methylone was first synthesized by the chemists Peyton Jacob III and Alexander Shulgin in 1996 for potential use as an antidepressant. Starting around 2004, methylone has been sold for recreational use, taking advantage of the absence of legal prohibition of this compound in many countries.

Methylone acts as a mixed reuptake inhibitor/releasing agent of serotonin, norepinephrine, and dopamine.

 In comparison to MDMA, it has approximately 3x lower affinity for the serotonin transporter, while its affinity for the norepinephrine and dopamine transporters is similar.[2][8] Notably, methylone's affinity for the vesicular monoamine transporter 2 (VMAT2) is about 13x lower than that of MDMA.

The results of these differences in pharmacology relative to MDMA are that methylone is less potent in terms of dose, has more balanced catecholaminergic effects relative to serotonergic, and behaves more like a reuptake inhibitor like methylphenidate than a releaser like amphetamine; however,

methylone has relatively robust releasing capabilities, perhaps due to its ability tophosphorylate the monoamine transporters being similar in potency relative to MDMA

Methylone (also known as "3,4-methylenedioxy-N-methylcathinone", "MDMC", "βk-MDMA" and by the slang term "M1") is an empathogen and stimulant psychoactive drug. It is a member of the substituted amphetamine, substituted cathinone and substituted methylenedioxyphenethylamine classes.

Methylone is the substituted cathinone analog of MDMA and the 3,4-methylenedioxy analog of methcathinone. The only structural difference of methylone with respect to MDMA is the substitution of 2 hydrogen atoms by 1 oxygen atom in the β position of the phenethylamine core, forming a ketone group.

 
Advantages:
1. Samples are provided for test;
2. Good quality products;
3. 100% secure delivery.
 
Payment ways: Western Union, Moneygram, Bitcoin, T/T
Delivery: EMS/ EUB/ USPS/ UPS/ TNT/ FEDEX/ DHL etc
Packaging: safe and discreet packaging

Company Introduction

Dongmao Biotechnology Co., Limited specializes in exporting high quality Research chemical, medical intermediate, Pharmaceutical chemicals and so on.

Products: Cannabinoids(5f-adb, bb-22, sdb-005......); Stimulants(a-pvp, M1, Methylone, he-xen, pvp......);

Hot sell products: U-47700, Fu-F, CEC

Our products are produced on the basis of best technical team, advanced equipment, high qualified management which meets the requirements of security and environmental protection.

We earned customers' trust and created a good reputation during these years. we are committed to providing excellent quality products and the perfect service to friends all over the world.

We will provide the most comprehensive products and service to you!

We are looking forward to your cooperation.